Argonne National Laboratory Center for Nanoscale Materials U.S. Department of Energy

Nanobio Interfaces Capabilities


  • Synthesis of metal oxide, semiconducting, metallic, and magnetic nanoparticles
  • Self-assembly of monodisperse nanoparticles into two- and three-dimensional crystals and binary superlattices
  • Bioconjugation and biochemical techniques with a focus on the synthetic biology and recombinant DNA/protein techniques
  • Peptide synthesis (CSBio CS136XT)
  • Functionalization of nanocrystalline surfaces with biomolecules, such as DNA, peptides, proteins and antibodies, using biochemical, electrochemical, and photochemical techniques


  • Centrifuges (Beckman Coulter Optima L-100 XP Ultracentrifuge and Avanti J-E Centrifuge)
  • Biological safety cabinets [Labconco Purifier Delta Series (Class II, B2)]
  • Glovebox (MBraun LabMaster 130)
  • Schlenk lines
  • Solvent purification (MBraun Auto SPS)
  • Lyophilizer
  • Harrick plasma cleaner


  • Structure and dynamics of hybrid bio-inorganic nanoscale assemblies and their response to external stimuli (light, voltage, and magnetic fields)
  • Nanoparticles and their interfaces using X-ray, microscopy, and photonic techniques, including chemiluminescence
  • Single-particle, X-ray nanoprobe characterization of biomolecular machines and hybrid bio-inorganic nanoparticles
  • Integration and characterization of nanoparticles in solid matrixes capable of ionic conductivity for solar energy conversion applications
  • Integration and characterization of hybrid nanocomposites with biological entities, such as cell organelles, and the use of external stimuli to achieve redox-sensitive cellular labeling as well as manipulation of cellular metabolism
  • Spectroscopic, microscopic, scanning probe techniques, including collaborative interactions with the X-Ray Nanoprobe, Nanophotonics and Electronic & Magnetic Materials & Devices groups, for single-particle, patterned-array, and thin-film characterization
  • Structural details at an atomic level via transmission electron microscopy (TEM) to examine crystal structures and defects, and structure-property relationships for nanostructures of different shapes and compositions. EDS/EFTEM/EELS allow qualitative/quantitative elemental composition analysis. In situ TEM capabilities are possible with CNM's electrochemical, biasing, and heating holders. Three-dimensional structural information can be achieved by the tomography technique. Rather than serving as a single-purpose instrument, the TEM facility is meant to complement broader nanoscience and nanotechnology projects taking place within the CNM. Contact Yuzi Liu ( for more information.


  • Gas chromatography/mass spectrometry, GC-MS (Agilent 5975C Series GC/MSD)
  • Electrochemical workstation (BASi Epsilon) potentiostat/galvanostat with rotating electrode capability
  • Field emission scanning electron microscope (JEOL JSM7500F)
  • Electron paramagnetic resonance spectroscopy
  • Laser scanning confocal microscope (Zeiss LSM 510 Meta)
  • Malvern ZetaSizer Nano (particle size potential)
  • Circular dichroism spectrometer (Jasco J-815)
  • Transmission electron microscope (JEOL JEM-2100F)

More Nanobio information


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The Center for Nanoscale Materials is an Office of Science User Facility operated for
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